Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1997-04-02
1999-12-28
Degen, Nancy
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435 6, 435 691, 4353201, 435325, 536 231, 536 235, C12N 1585, C12N 1511, C07H 2104, C07H 2102
Patent
active
060080507
ABSTRACT:
Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
REFERENCES:
GenBank Accession #1640787 Apr. 19, 1997.
P. Chalon, et al., "Molecular cloning of a levocabastine-sensitive neurotensin binding site", FEBS vol. 386, pp. 91-94 (1996).
J. Mazella, et al., "Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain", The Journal of Neuroscience, vol. 16 5613-5620, Sep. 15, 1996.
Bergsma Derk Jon
Shabon Usman
Degen Nancy
Han William T.
King William T.
McGarry Sean
SmithKline Beecham Corporation
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