Cytoplasmic expression of antibodies, antibody fragments and ant

Details Cytoplasmic expression of antibodies, antibody fragments and ant Cytoplasmic expression of antibodies, antibody fragments and ant

1996-04-10

1999-12-28

Reeves, Julie

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 696, 435170, 435183, 435189, 435471, 43525233, 435849, 5303873, 4241341, 424801, 536 232, 536 234, 536 2353, C07H 2102, C07H 2104, C12N 1513, C12N 1503

Patent

active

06008023&

ABSTRACT:
The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

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