Immunomagnetic detection and isolation of cancer cells

Details Immunomagnetic detection and isolation of cancer cells Immunomagnetic detection and isolation of cancer cells

1997-09-29

1999-12-28

Scheiner, Laurie

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 72, 435 75, 435 794, 436 64, 436526, G01N 33574

Patent

active

060080027

ABSTRACT:
A composition and method are provided for detecting and isolating antigen associated cancer cells. The composition and method utilize an antigen specific, immunomagnetic composition as the detecting and isolating agent. An illustrative immunomagnetic composition comprises avidin or streptavidin conjugated to paramagnetic beads and further conjugated to antigen specific, biotinylated antibody. A fluidic admixture of the antigen associated cancer cells with the immunomagnetic composition in an affinity column disposed in a magnetic field produces a cancer cell immunomagnetic composition conjugate which is deposited onto the inner wall of the column.

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Durrant et al. Br J Cancer vol. 60 533-537, 1989.

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