Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory

Details Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory Benzenesulphonamide derivatives having 5-lipoxygenase inhibitory

1994-02-01

1995-04-04

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514445, 514446, 514451, 514471, 549 28, 549 62, 549 65, 549 67, 549416, 549417, 549419, 549423, 549475, 549476, 549478, A61K 3139, A61K 31395, C07D33304, C07D31500

Patent

active

054038570

ABSTRACT:
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R.sup.2 and R.sup.3 together form -A.sup.2 -X.sup.2 -A.sup.3 - which defines a ring having 5 or 6 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl; A.sup.1 is a direct link to X.sup.1 or is (1-3C) alkylene; X.sup.1 is oxy, thio or imino; Ar is optionally substituted phenylene; R.sup.4 is (1-4C)alkyl, fluoro-(2-4C)alkyl or optionally substituted phenyl or a heterocyclic moiety; R.sup.5 is hydrogen or (1-4C)alkyl; and R.sup.6 is hydrogen, halogeno, trifluoromethyl, (1-4C)alkyl or (1-4C)alkoxy; or a pharmaceutically-acceptable salt thereof;
processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.

REFERENCES:
patent: 5098930 (1992-03-01), Edwards et al.
patent: 5098932 (1992-03-01), Hamon
patent: 5134148 (1992-07-01), Carley et al.
patent: 5208259 (1993-05-01), Bird et al.
patent: 5217969 (1993-06-01), Bruneau et al.
patent: 5217977 (1993-06-01), Crawley et al.
patent: 5221677 (1993-06-01), Crawley et al.
patent: 5254581 (1993-10-01), Bruneau et al.

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