Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-01-31
1995-04-04
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514414, 514419, 514913, A61K 3140
Patent
active
054038561
ABSTRACT:
The invention relates to a method of treating cardiac insufficiency by using compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denote hydrogen or an organic radical and R.sup.4 R.sup.5, together with the atoms carrying them, form a mono-, bi- or tri-cyclic heterocyclic ring system. The invention furthermore relates to compounds of the formula I and agents containing these for use in the treatment of the abovementioned disease.
REFERENCES:
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4374847 (1983-02-01), Gruenfeld
patent: 4425355 (1984-01-01), Hoefle et al.
patent: 4442089 (1984-04-01), Horovitz
patent: 4508729 (1985-04-01), Vincent et al.
patent: 4515803 (1985-05-01), Henning et al.
patent: 4525301 (1985-06-01), Henning et al.
patent: 4558064 (1985-12-01), Teetz et al.
patent: 4558065 (1985-12-01), Urbach et al.
patent: 4562202 (1985-12-01), Urbach et al.
patent: 4584285 (1986-04-01), Doll et al.
patent: 4587258 (1986-05-01), Gold et al.
patent: 4591598 (1986-05-01), Urbach et al.
patent: 4614805 (1986-09-01), Urbach et al.
patent: 4620012 (1986-10-01), Henning et al.
patent: 4624962 (1986-11-01), Henning et al.
patent: 4659838 (1987-04-01), Lerch
patent: 4668796 (1987-05-01), Geiger et al.
patent: 4668797 (1987-05-01), Urbach et al.
patent: 4678800 (1987-07-01), Stanton et al.
patent: 4684662 (1987-08-01), Henning et al.
patent: 4691022 (1987-09-01), Henning et al.
patent: 4714708 (1987-12-01), Urbach et al.
patent: 4727160 (1988-02-01), Teetz et al.
patent: 4808573 (1989-02-01), Gold et al.
patent: 4818749 (1989-04-01), Gold et al.
patent: 4822894 (1989-04-01), Geiger et al.
patent: 4831157 (1989-05-01), Gold et al.
patent: 4849524 (1989-07-01), Henning et al.
patent: 4868307 (1989-09-01), Barton et al.
patent: 4879403 (1989-11-01), Teetz et al.
patent: 4886827 (1989-12-01), Urbach et al.
patent: 4920144 (1990-04-01), Urbach et al.
patent: 4983623 (1991-01-01), Henning et al.
patent: 4997260 (1990-12-01), Henning et al.
patent: 5053519 (1991-10-01), Teetz et al.
patent: 5055483 (1991-10-01), Ruger et al.
patent: 5061722 (1991-10-01), Teetz et al.
patent: 5098910 (1992-03-01), Becker et al.
Effect of Ramipril on Mortality and Morbidity of Survivors of Acute Myocardial Infaction With Clinical Evidence of Heart Failure, The Acute Infaction Ramipril Efficacy (AIRE) Study Investigators, The Lancet, Oct. 2, 1993, vol. 342, No. 8875, pp. 821-828.
Ryozo Koshiura et al., "Naibumpi Yakuri" (Endocrinological Pharmacology), pp. 136-137, (Jun. 10, 1983). (Translation of passage attached).
Bernward Scholkens, et al., "Experimental Cardiovascular Benefits of Angiotensin-Converting Enzyme Inhibitors: Beyond Blood Pressure Reduction", J. Cardiovasc. Pharmacol., vol. 18 (Supp. 2), pp. S26-S30 (1991).
Dialog.RTM. Search, Sep. 14, 1992.
Gold U.S. patent application Ser. No. 258,484, filed Apr. 28, 1981.
Leonard et al., J. Am. Chem. Soc., 77, 439 (1955).
Leonard et al., J. Am. Chem. Soc., 78, 3457 (1956).
Leonard et al., J. Am. Chem. Soc., 78, 3463 (1956).
Leonard et al., J. Am. Chem. Soc., 81, 5627 (1959).
Koelsch et al., J. Org. Chem., 26, 1104 (1961).
Griot et al., Hely. Chim. Acta, 42, 121 (1959).
Bonnett et al., J. Chem. Soc., 2087 (1959).
Battersby et al., J. Chem. Soc., 4333 (1958).
Rosenblatt et al., The Chemistry Of Functional Groups. Supplement F: The Chemistry of Amino, Nitroso and Nitro Compounds And Their Derivatives. Part II, S. Patai, ed., Wiley & Sons: New York 1982, pp. 1100-1104.
L. W. Haynes, Enamines, A. G. Cook, ed., Marcel Decker, Inc.: 1969, pp. 68-79, 261-269, 413.
Fieser & Fieser, Reagents For Organic Synthesis, vol. 1, pp. 644-651 (1967).
Boehme et al., Iminium Salts in Organic Chemistry, Part I (E. C. Taylor, ed.), Wiley & Sons: New York, 1976, p. 143.
S. Dayagi et al., The Chemistry Of Functional Groups. The Chemistry Of The Carbon-Nitrogen Double Bond, S. Patai, ed., Wiley & Sons: New York, 1970, p. 119.
W. Greenlee et al., J. Med. Chem., 28, 434-442 (1985).
K. Ogawa et al., J. Chem. Soc., Perkin Trans. I, 3031-3035 (1982).
R. Bacon and D. Stewart, J. Chem. Soc. (C), 1384-1387 (1966).
R. Bacon et al., J. Chem. Soc. (C), 1388-1389 (1966).
Patchett et al., Nature, 288, 280-283 (1980).
Booth et al., Chemistry and Industry, 466-467 (1956).
Booth et al., J. Chem. Soc., Part I, 1050-1054 (1959).
Murakoshi et al., Chemical Abstracts, 61, 9465(e)(1964).
Cushman et al., Fed. Proc., 38 (13), 2778-2782 (1979).
Houben-Weyl, Methoden der Organischen Chemie, 7(2b), 1403-1404 (1976).
Katritskaya, Dzh. Lagorskaya Khimia Geterosikl. Soedin., Moskow 1963, pp. 155-158.
Anderson, Jr. et al., J. Org. Chem., 43(1), 54-57 (1978).
Bertho et al., "Synthesen In Der 2-Azabicyclo[0.3.3]-octan-Reihe", Chemische Berichte, 92(7), 2218-2235 (1959).
Farkas et al., J. Org. Chem., 22, 1261-1263 (1957).
Taylor et al., J. Org. Chem., 38(16), 2817-2821 (1973).
Taylor et al., Heterocycles, 25, 343-345 (1987).
English language translation of Mitzlaff et al., Liebig's Ann. Chem., 1713-1733 (1978).
Quarterly Reviews 25: 323-341 (1971), Boyle.
Chem. Berichte 86: 1524-1528 (1953), Langenbeck, Herbst.
Chem. Abst. 49(1955)3009c, Langenbeck, Herbst.
Xiang et al. Chem Abstracts, CA (100):150853c (1984), p. 3.
The Merck Manual, 15th Ed., (1987), Berkow M. D. editor, pp. 401, 428-429.
Gavras et al, Circulation, vol. 58, No. 5 (1978), pp. 770-776.
Acler et al., Circulation, vol. 61, No. 5 (1980), p. 931-937.
Drug Evaluations, 6th ed. (1986), American Medical Association, pp. 429-434 and 535-536.
Teetz, CA(100):52012h (1984), p. 617.
Urbach, CA(100):139616g (1984), p. 702.
Urbach, CA(100):139617h (1984), p. 702.
Henning, CA(100):210436f (1984), p. 655.
Geiger, CA(97):92759h (1982), p. 819.
Teetz et al, Chemical Abstract vol. 99, No. 158854k (1983).
Gross, F., Chemical Abstract vol. 100, No. 151036a (1983).
Urbach et al., Chemical Abstract vol. 103, No. 160858j (1985).
Stedman's Medical Dictionary, 22nd Ed. (1972), The Williams and Wilkins Company, Baltimore, p. 638.
Geiger Rolf
Henning Rainer
Scholkens Bernward
Teetz Volker
Urbach Hansjorg
Datlow Philip I.
Hoechst Aktiengesellschaft
Shah Mukund J.
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