Substituted N-aryl-1,2-diaminocyclobutene-3,4-diones

Details Substituted N-aryl-1,2-diaminocyclobutene-3,4-diones Substituted N-aryl-1,2-diaminocyclobutene-3,4-diones

1994-06-13

1995-04-04

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483355, 558414, 562457, 562458, 564 84, 564 90, 564 92, 564 98, 564 99, 564161, 564180, 564182, 564217, 564218, 564102, 564 94, 564431, 514601, 514602, 514604, 514608, 514613, 514617, 514629, 514630, 514576, 514646, A61K 31135, C07C 8750

Patent

active

054038537

ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, straight or branched chain alkyl or mono- or bi-cyclic alkyl;

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patent: 5212283 (1993-05-01), St. Clair
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Neuse, Chemical Abstracts, vol. 79, No. 10 Abstract 65854g, p. 406, Sep. 10, 1973.
Tietze, et al., Squaric Acid Diethyl Ester: A New Coupling Reagent for the Formation of Drug Biopolymer Conjugates. Synthesis of Squaric Acid Ester Amides and Diamides, Chem. Ber., 124, p. 1215, 1991.
Tietze, et al., Conjugation of p-Aminophenyl Glycosides with Squaric Acid Diester to a Carrier Protein and the Use of Neoglycoprotein in the Histochemical Detection of Lectins, Bionconjugate Chem., 2, p. 148, 1991.
Ehrhardt, et al., Amide und Thioamide der Quadratsaure: Synthese und Reaktionen, Chem. Ber., 110, p. 2506, 1977.
Neuse, et al., Amidierung von Quadratsaure-estern, Liebigs Ann. Chem., p. 619, 1973.

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