Purification and characterization of MHC-peptide complexes usefu

Details Purification and characterization of MHC-peptide complexes usefu Purification and characterization of MHC-peptide complexes usefu

1995-06-06

1999-12-28

Allen, Marianne P.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

530412, 530413, A61K 39385

Patent

active

060078200

ABSTRACT:
The present invention provides a method for the purification and characterization of MHC-peptide complexes useful in ameliorating immunological disorders, such as, for example, autoimmune diseases, allergic responses and transplant responses. The method disclosed is a one-step method based on the use of metal chelate affinity chromatography to separate the MHC-peptide complexes of interest from both uncomplexed MHC molecules and other endogenous MHC-peptide bound complexes.

REFERENCES:
patent: 5260422 (1993-11-01), Clark et al.
Demotz et al. PNAS 88:8730-34, Oct. 1991.
Arnold Bioitechnolgy 9:151-156, Feb. 1991.

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