Biocompatible, low protein adsorption affinity matrix

Details Biocompatible, low protein adsorption affinity matrix Biocompatible, low protein adsorption affinity matrix

1991-04-08

1995-04-04

Acquah, Samuel A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

528 48, 528 52, 528 53, 528 59, 528904, 427 213, 4272071, 427221, 427435, 21050024, 4284231, 4284239, 4284242, 4284246, 4284251, 4284255, 4284256, 604 8, 604 19, 604403, 435174, 435176, 435181, 435182, 525403, 525418, 525420, 525424, 525454, 436120, 436129, 436131, G01N 33545

Patent

active

054037506

ABSTRACT:
Affinity matrices useful for the chromatography and immobilization of biological materials and the method of preparing and using the same are disclosed. The affinity supports are based on hydrated polyurethane polymers which have been activated to provide a means for covalently attaching a variety of bioaffinity agents. The hydrated polymer matrices are characterized by their biocompatibility and resistance to nonspecific protein adsorption. Preferably, the prepolymers used to prepare the hydrated polymers are isocyanate-capped oxyethylene-based diols or polyols, at least 75% of said diols and polyols having a molecular weight of 7000 to about 30,000.

REFERENCES:
patent: 3905923 (1975-09-01), Klug
patent: 3939123 (1976-02-01), Matthews et al.
patent: 4094744 (1978-06-01), Hartdegen et al.
patent: 4177038 (1979-12-01), Biebricher et al.
patent: 4182827 (1980-01-01), Jones et al.
patent: 4226935 (1980-10-01), Fusee
patent: 4241537 (1980-12-01), Wood
patent: 4266030 (1981-05-01), Tschang et al.
patent: 4371611 (1983-02-01), Fusee
patent: 4412000 (1983-10-01), Lehamnn et al.
patent: 4439585 (1984-03-01), Gould et al.
patent: 4485227 (1984-11-01), Fox
patent: 4569981 (1986-02-01), Wenzel et al.
patent: 4681851 (1987-07-01), Baumgarten et al.
patent: 4794090 (1988-12-01), Parham et al.
patent: 4885250 (1989-12-01), Eveleigh et al.
patent: 4940737 (1990-07-01), Braatz et al.

Affiliated with

Also associated with

Rating

Biocompatible, low protein adsorption affinity matrix does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Biocompatible, low protein adsorption affinity matrix, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Biocompatible, low protein adsorption affinity matrix will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2380214