Method for reversibly increasing proliferation of a non-malignan

Details Method for reversibly increasing proliferation of a non-malignan Method for reversibly increasing proliferation of a non-malignan

Filed on

1992-01-08

Date issued

1994-06-28

Examiner

Hill, Jr., Robert J.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Spore forming or isolating process

Other Related Categories

435 6, 4351723, 935 10, 935 23, 935 52, 536 231, 536 235, 536 2372, 514 44, C12N 500, A61K 3170, C07H 1700, A01N 4304

Type

Patent

Status

active

Patent number

053246543

Description

ABSTRACT:
A method and composition for reversibly increasing the proliferation of cells in vitro. Cell populations are treated in vitro with antisense oligonucleotides to a tumor suppressor gene, such as the retinoblastoma (Rb) gene. Such treatment inhibits expression of the tumor suppressor gene product and results in a reversible increase in the proliferation of the cell population.

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