Method of conferring resistance to retroviral infection

Details Method of conferring resistance to retroviral infection Method of conferring resistance to retroviral infection

1991-07-29

1994-06-28

Stone, Jacqueline

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 911, 435 913, 4351723, 4352401, 4352402, 536 231, 935 3, 935 6, 935 34, 935 70, C12N 1511, C12N 510, C07H 2102, C07H 2104

Patent

active

053246438

ABSTRACT:
In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or homologous, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting retroviral replication and/or interfering with assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using cells upon which resistance to infection has been conferred.

REFERENCES:
patent: 4806463 (1989-02-01), Goodchild et al.
H. Mitsuya et al. (1987), Nature 325: 773-778.
E. C. M. Mariman (1985) Nature 318: 414.
R. Tellier et al. (1985) Nature 318: 414.
L.-J. Chang et al (1987) J. Virology 61(3): 921-924.
I. Herskowitz (1987) Nature 329: 219-222.

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