Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-02-01
1984-02-14
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
424273R, 542458, 542468, 548346, C07D23356
Patent
active
044318154
ABSTRACT:
A method for (i) the treatment or prophylaxis of a thrombo-embolic disorder of a mammal or a mammalian tissue (ii) the prevention, treatment or prophylaxis of angina pectoris, or (iii) the prevention or delay of the onset of shock, which comprises the administration to the mammal or mammalian tissue of a non-toxic, effective amount of an imidazole of the formula: ##STR1## in which A is a straight or branched, saturated or unsaturated acyclic hydrocarbon radical of from 1 to 3 carbon atoms, n is 0 or 1, and R is ##STR2## wherein m is 0 or an integer which is at least 1 and the or each Q substituent, which, when m is greater than 1 may be the same or different is selected from a saturated or unsaturated hydrocarbon group of from 1 to 4 carbon atoms; alkoxy of from 1 to 4 carbon atoms; nitro; phenyl; acyloxy; halo; trihalomethyl; hydroxy; carboxyl; a salt of such a carboxyl group; carboalkyloxy; carboaryloxy; carboarylalkyloxy; --NR.sup.6 R.sup.7 and --CONR.sup.6 R.sup.7, in which R.sup.6 and R.sup.7 may be the same or different and are each hydrogen or alkyl of from 1 to 4 carbon atoms; the imidazole being the free base or a pharmaceutically acceptable salt thereof.
Pharmaceutical formulations of some inidazoles within the class suitable for use in the method of treatment are also novel. Methods of preparing the imidazoles are provided.
REFERENCES:
patent: 3769422 (1973-10-01), Timmler et al.
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patent: 4006243 (1977-02-01), Strehlke et al.
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patent: 4105762 (1978-08-01), Miller et al.
Baggaley, K., et al., J. Med. Chem., 18(8), 833-836 (1975).
Brown Donald
Burroughs Wellcome Co.
Schwartz Richard A.
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