Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-12-09
1998-07-28
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3133, A61K 31535
Patent
active
057863490
ABSTRACT:
A method for treatment of diseases caused by Chlamydia infection is disclosed comprising administering a rifamycin of the formula (I): ##STR1## wherein R.sup.1 is hydrogen atom or acetyl, and X is oxygen, sulfur or a group NR, in which R is hydrogen, an alkyl group having 1 to 7 carbon atoms or a group of the formula (II): ##STR2## in which n is an integer of 1 to 3; or a physiologically acceptable salt thereof.
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Abstract 2.05, "The Third International Conference on the Macrolides, Azalides and Strepyogramins", Jan. 24-26, 1996.
Jones et al., "In Vitro Activity of Rifamycins Alone or in Combination with Other Antibiotics Against Chlamydia Trachomatis", Reviews of Infectious Diseases, vol. 5, No. Suppl. 3, Jul. 1983-Aug. 1983, USA, pp. S556-S562.
Becker, "Antitrachoma Activity of Rifamycin B and 8-0-Acetylrifamycin S", Nature, vol. 231, 14 May 1971, USA, pp. 115-116, XP000647315.
T. Yamane et al., "Synthesis and Biological Activity of 3'-Hydroxy-5'-aminobenzoxazinorifamycin Drivatives", Chemical and Pharmaceutical Bulletin, vol. 41, No. 1, 1993, Japan, pp. 148-155, XP000197109.
Treharne et al., "In Vitro Studies of Chlamydia trachomatis Susceptibility and Resistance to Rifampin and Rifabutin", Antimicrobial Agents and Chemotherapy, vol. 33, No. 8, Aug. 1989, pp. 1393-1394.
Blamire et al., Proc. Nat. Acad. Sci. 71 (70), pp. 2867-2871, Jul. 1974.
Hidaka Takayoshi
Hosoe Kazunori
Shawar Ribhi M.
Todaro George
Yamashita Katsuji
Kaneka Corporation
Spivack Phyllis G.
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