Method of use of enantiomers of trans-indeno[1,2-b]-1,4-oxazines

Details Method of use of enantiomers of trans-indeno[1,2-b]-1,4-oxazines Method of use of enantiomers of trans-indeno[1,2-b]-1,4-oxazines

Filed on

1982-08-02

Date issued

1984-02-14

Examiner

Raymond, Richard

Patent Class

Drug, bio-affecting and body treating compositions

SubClass

Antigen, epitope, or other immunospecific immunoeffector

SubSubClass

Bacterium or component thereof or substance produced by said...

Other Related Categories

4242484, 544101, A61K 31535

Type

Patent

Status

active

Patent number

044316470

Description

ABSTRACT:
The (R,R)-enantiomers of trans-indeno[1,2-b]-1,4-oxazines demonstrate dopaminergic activity, whereas the (S,S)-enantiomers demonstrate .alpha.-adrenergic antagonist activity. They are prepared by cyclization of the appropriate chiral 2-amino-1-hydroxyindane.

REFERENCES:
patent: 3642789 (1972-02-01), Faith et al.
McClure et al., J. Org. Chem., 46, 2431 (l981).
Craig et al., J. Org. Chem., 39, 1669 (1974).

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