Hydantoin therapeutic agents

Details Hydantoin therapeutic agents Hydantoin therapeutic agents

1977-05-23

1978-12-19

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, C07D49110, C07D49510

Patent

active

041307143

ABSTRACT:
Several novel dextrotatory spiro-hydantoin compounds have been obtained by resolving the corresponding dl-compounds which are initially synthesized by first condensing the appropriate carbonyl ring compound, such as the corresponding 4-chromanone or thiochroman-4-one, as the case may be, with potassium cyanide and ammonium carbonate. The resulting optically-active hydantoin derivatives, such as d-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione and d-6'-fluoro-spiro-[imidazolidine-4,4'-thiochroman]-2,5-dione, are particularly useful in preventing or alleviating chronic diabetic complications.

REFERENCES:
patent: 2683718 (1954-07-01), Dornfeld et al.
Arnold et al. Chem. Abst. 1963, vol. 58, cols. 3439-3440.
Boehme et al. Chem. Abst. 1974, vol. 80, No. 108305u.
Karrer et al. Organic Chemistry 2nd English ed. pp. 93-99, N.Y., Elsevier, 1946.

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