Synthesis of biotin

Details Synthesis of biotin Synthesis of biotin

1977-06-17

1978-12-19

Trousof, Natalie

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424273R, C07D49504

Patent

active

041307127

ABSTRACT:
A procedure for the synthesis of biotin is disclosed whereby unsaturated diacylated biotin precursors are catalytically hydrogenated with the substantial absence of sulfur poisoning. The hydrogenation procedure dislcosed herein results in optically pure biotin.

REFERENCES:
patent: 2487051 (1949-11-01), Mozingo
patent: 2502422 (1950-04-01), Cheney
patent: 4054740 (1977-10-01), Field
Wagner et al. Synthetic Organic Chem. p. 567, John Wiley & Sons, N.Y. 1953.
Allinger et al., Organic Chem., Worth, N.Y. 1972. pp. 532-533.

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