Styrylamidines

Details Styrylamidines Styrylamidines

1978-04-10

1978-12-19

Schwartz, Gerald A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424280, 424316, 424321, 424324, A61K 31155

Patent

active

041306635

ABSTRACT:
Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

REFERENCES:
patent: 3413345 (1968-11-01), Mull
Matier et al., "Formation of 5-aryl-1,2,4-thiadiazine-1,1-dioxides and Strylamidines from Strylsulfonylamidines," 4th Int'n Congress of Heterocyclic Chemistry, Salt Lake City, Utah (Jul. 1973).
Madison & Boyd, "Organic Chemistry," pp. 111-112, 526-534 (1962).

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