Method of preparing giant size liposomes

Details Method of preparing giant size liposomes Method of preparing giant size liposomes

1984-01-14

1985-07-30

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 424 38, 4284022, 436829, B01J 1302, A61K 952

Patent

active

045320896

ABSTRACT:
Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosmotic medium. The freeze-thaw cycles aggregate the vesicles and increase their internal concentration of polar compound. During dialysis the vesicles imbibe water, rupture, and form enlarged liposomes.

REFERENCES:
patent: 3957971 (1976-05-01), Oleniacz
patent: 4016100 (1977-04-01), Suzuki et al.
patent: 4133874 (1979-01-01), Miller et al.
Huntress: The Preparation, Properties, Chemical Behavior, and Identification of Organic Chlorine Compounds, John Wiley & Sons, Inc., New York, (1948), pp. 138-141.
Kasahara et al.: "Reconstitution and Purification of the D-Glucose Transporter from Human Erythrocytes", J. Biol. Chem., 252, (1977): 7384-7390.
Pick: "Liposomes with a Large Trapping Capacity Prepared by Freezing and Thawing of Sonicated Phospholipid Mixtures", Arch. Biochem. Biophys., (1981), 212: 186-194.

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