Substituted mercaptothiadiazole compounds

Details Substituted mercaptothiadiazole compounds Substituted mercaptothiadiazole compounds

1977-09-16

1979-03-13

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260307A, 260307G, 260308R, 260308C, 560141, 560169, C07D24912, C07D27110, C07D28512

Patent

active

041442407

ABSTRACT:
A series of novel 7-(D-.alpha.-aminophenylacetamido)- and 7-(D-.alpha.-hydroxyphenylacetamido)-.DELTA..sup.3 -cephem derivatives have been prepared wherein a heterocyclic thiomethyl moiety is located at the 3-position of the molecule. These compounds are useful as antibacterial agents for the treatment of diseases caused by Gram-positive and Gram-negative bacteria. Preferred members include 7-(D-.alpha.-hydroxyphenylacetamido)-3-(3-carbamoyl-1,2,4-triazol-5-yl)thi omethylceph-3-em-4-carboxylic acid and 7-(D-.alpha.-hydroxyphenylacetamido)-3-(2-carboxymethoxy-methyl-1,3,4-thia diazol-5-yl)thiomethylceph-3-em-4-carboxylic acid. Alternative methods of preparation are provided for these compounds, including various synthetic routes leading to the required novel heterocyclic thiol intermediates.

REFERENCES:
patent: 3794661 (1974-02-01), Boehner et al.
patent: 3809701 (1974-05-01), Dawes et al.

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