Substituted azetidin-2-one antibiotics

Details Substituted azetidin-2-one antibiotics Substituted azetidin-2-one antibiotics

1977-11-30

1979-03-13

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

546275, 2603066R, 2603068D, 260307R, 260307H, 260307D, 260308D, 2603068A, 2603372R, 2603474, 2603067C, 542454, 424244, 548316, C07D20508, A61K 31395, C07D27760

Patent

active

041442326

ABSTRACT:
Monocyclic .beta.-lactam antibiotics of the formula ##STR1## WHEREIN R is amino or acylamino, e.g., phenylacetylamino, phenylglycylamino and 2-[4-(3-amino-3-carboxypropoxy)phenyl]-2-hydroximinoacetylamino; R.sub.1 is H or ester forming group; R.sub.2 is H, --OCH.sub.3, --SCH.sub.3, or --CH.sub.3 ; and R.sub.3 is H or acetoxy; are useful antibacterials for controlling .beta.-lactamase producing gram-negative bacteria and other pathogens. Intermediates useful in the preparation of the antibiotics and a novel process for preparing 4.alpha.-acetoxy substituted azetidin-2-ones are provided.

REFERENCES:
patent: 3487071 (1969-12-01), Sheehan
patent: 3923977 (1975-12-01), Aoki et al.
Kamiya et al., Chem. Abs., 85, 21078, (1976).

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