Processes for the production of 3',4'-dideoxykanamycin B

Details Processes for the production of 3',4'-dideoxykanamycin B Processes for the production of 3',4'-dideoxykanamycin B

1977-11-14

1979-10-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 17R, 424180, C07H 1522

Patent

active

041699394

ABSTRACT:
A clinically valuable antibiotic, 3',4'-dideoxykanamycin B is now produced by a reduced number of consecutive steps in an improved overall yield by new processes starting from kanamycin B via intermediate derivatives of kanamycin B in which all the five amino groups are protected with an unsubstituted or substituted benzyloxycarbonyl group and possibly the 2"-hydroxyl group may be protected with a lower alkylsufonyl, arylsulfonyl or aralkylsulfonyl group.

REFERENCES:
patent: RE28647 (1975-12-01), Umezawa et al.
patent: 3868360 (1975-02-01), Daniels et al.
patent: 3929762 (1975-12-01), Umezawa et al.
Umezawa, S. et al., Bull. Chem. Soc. Japan, 45 (12), 3624-3628 (1972).
Jikihara, T. et al., Bull. Chem. Soc. Japan, 46 (11), 3507-3510 (1973).
Umezawa et al., Jour. of Antibiotics, XXIV (7), 485-487 (1971).
Umezawa et al., Jorn. of Antibiotics, XXV (12), 743-745 (1972).

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