Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-01-24
1981-12-22
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 22, 544 26, 544 27, 544 28, A61K 31545, C07D50134
Patent
active
043070906
ABSTRACT:
Novel oximes of the syn isomers of 7-(2-amino-4-thiazolyl)-acetamido-cephalosporanic acid of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, chlorine, methoxy, alkyl and alkylthio of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, acetoxymethyl, carbamoyloxymethyl, ##STR2## A1K is 1 to 4 carbon atoms, azidomethyl and --CH.sub.2 --S--R' and R' is selected from the group consisting of a nitrogen heterocycle optionally substituted, acyl of an alkanoic acid of 2 to 4 carbon atoms, 2-oxo-(3H)-thiazolin-4-yl-carbonyl and 3-methyl-1,2-oxazol-5-ylcarbonyl, n is an integer from 2 to 4, R.sub.1, R.sub.2 and R.sub.3 are individually alkyl of 1 to 4 carbon atoms or together taken with the nitrogen atom they are attached to form a group selected from the group consisting of 1,4-diazobicyclo (2,2,2)octan-1-ylium and 1,3,5,7-tetraazatricyclo(3,3,1,1.sup.3,7) decan-1-ylium and their non-toxic, pharmaceutically acceptable acid addition salts having antibacterial properties and process for their preparation and novel intermediates.
Heymes Rene
Vignau Michael
Coughlan, Jr. Paul M.
Roussel Uclaf
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