Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-02-23
1996-01-02
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
568808, C07D31770
Patent
active
054810078
ABSTRACT:
Bioactive ABC taxoids accessible by convergent synthesis have an intact AB ring framework of taxol, including the C.sup.13 side chain, and an aromatic C ring which substitutes for the CD ring system found on native taxol. The aromatic C ring may be substituted or unsubstituted. MPT derivatives of ABC taxoids are also disclosed.
REFERENCES:
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Nicolaou et al., JACS, 116, pp. 1591-1592 (1994).
Masters, et. al, "A Concise Synthesis of a Highly Functionalized C-Aryl Taxol Analog by an Intramolecular Heck Olefination Reaction", Tet. Letters., 34: 7253-7256. (1993).
DiGrandi, et. al. " Synthesis of Component Nucleophiles for Delivering the A Ring of Taxol", J. Org. Chem., 58: 4989-4992 (1993).
Nicolaou, et. al. "Chemistry and Biology of Taxol", Angew. Chem. Int. Ed., 33: 15-44 (1994).
Nicolaou, et. al. "A Convergent Strategy Towards Taxol. A Facile Enantioselective Entry Into a Fully Functionalized Ring A System", J. Chem. Soc. Chem. Comm., 1117-1118, (1992).
Nicolaou, et. al. "Synthesis of a Fully Functionalized CD Ring System of Taxol", J. Chem. Soc. Chem. Comm., 1118-1119, (1992).
Nicolaou, et. al. "Synthesis of ABC Taxoid Ring Systems via a Convergent Strategy", J. Chem. Soc. Chem Commun., 1024-1025 (1993).
Claiborne Christopher F.
Couladouros Elias A.
Nantermet Philippe G.
Nicolaou K. C.
Sorensen Erik J.
Dees Jos,e G.
Frazier Barbara S.
Lewis Donald G.
The Scripps Research Institute
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