Process for preparation of 4-acetyl-2-substituted-imidazoles

Details Process for preparation of 4-acetyl-2-substituted-imidazoles Process for preparation of 4-acetyl-2-substituted-imidazoles

1983-04-11

1984-11-13

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23364

Patent

active

044827237

ABSTRACT:
Novel intermediates of the formula ##STR1## where R.sup.1 and R.sup.2 are each (C.sub.1 -C.sub.4)alkyl or taken together are (C.sub.2 -C.sub.4)alkylene, and their use in a process for preparation of compounds of the formula ##STR2## where R is (C.sub.1 -C.sub.6)alkyl or (CH.sub.2).sub.n Ar, Ar is phenyl or phenyl monosubstituted by Cl, Br, F, CH.sub.3 or OCH.sub.3 and n is 2 to 4; which comprises contacting one of said intermediates with an amidine of formula ##STR3## in the presence of reaction inert solvent and base; and a process for preparing a further intermediate, 1,2-dichloro-1-buten-3-one.

REFERENCES:
patent: 4374843 (1983-02-01), LaMattina et al.
Catch et al., J. Chem. Soc., (London), 278, (1948).
McLamore et al., J. Org. Chem., 20, 109, (1955).
Petrov, Chem. Abstr., 38, 1467.sup.4, (1944).

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