Therapeutically effective piperidyl N-(4-quinolyl)-anthraniloylo

Details Therapeutically effective piperidyl N-(4-quinolyl)-anthraniloylo Therapeutically effective piperidyl N-(4-quinolyl)-anthraniloylo

1982-11-12

1984-11-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546161, 546218, 546242, A61K 3147, C07D21544

Patent

active

044825617

ABSTRACT:
The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to 4 carbon atoms; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a benzyl, phenethyl, 4-nitrophenethyl or 4-aminophenethyl radical; or a phenacyl, benzoylethyl, .beta.-hydroxyphenethyl or .alpha.-hydroxyphenylpropyl radical, optionally substituted on the phenyl ring by one or more halogen atom, trifluoromethyl, nitro or amino substituents, or an alkyl substituent having from 1 to 4 carbon atoms or an alkoxy substituent having from 1 to 4 carbon atoms; R.sub.1 is a hydrogen atom or a phenyl radical; each of R.sub.2 and R.sub.3 is independently a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; one of R.sub.4 and R.sub.5 is a chlorine atom or a trifluoromethyl radical and the other of R.sub.4 and R.sub.5 is a hydrogen atom; and the pharmaceutically acceptable salts of such esters; are effective analgesics, anti-inflammatories and antidepressants; are also strong inhibitors of platelet aggregation, and thus too are useful in the treatment of cerebral thrombosis, cerebral and cardiac infarction, and arteriosclerotic disorders.

REFERENCES:
patent: 3131195 (1964-04-01), Rumpf et al.
patent: 3479360 (1969-11-01), Allais et al.
patent: 4259335 (1981-03-01), Beregi et al.

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