Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-08-26
1984-11-13
Rollins, Alton D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
260239BD, 2602393B, 548546, 560 21, 560 34, 564151, 564310, 564313, A61K 3155, C07D25504
Patent
active
044825471
ABSTRACT:
This invention relates to substituted-1,3,4-benzotriazepines of the formula ##STR1## wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R.sub.1 and R.sub.3 are each independently hydrogen or alkyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, Ar lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R.sub.1 and/or R.sub.3 in the above formula is hydrogen. The compound of this invention may be used as antihypertensive agents.
REFERENCES:
patent: 3176008 (1965-03-01), Sulkowski et al.
patent: 4309424 (1982-01-01), Martin et al.
Paal et al., Ber. Deut. Chem., vol. 25, pp. 2896-2904 (1892).
Kadin, J. Org. Chem., vol. 38, pp. 1348-1350 (1973).
Geyer, III et al., J. Med. Chem., vol. 25, pp. 340-346 (1982).
Fusco et al., Tetrahedron Letters, vol. 23, No. 17, pp. 1829-1830 (1982).
Martin Lawrence L.
Setescak Linda L.
Cartiglia James R.
Hoechst-Roussel Pharmaceuticals Inc.
Rollins Alton D.
LandOfFree
Substituted-1,3,4-benzotriazepines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted-1,3,4-benzotriazepines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted-1,3,4-benzotriazepines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2360598