Preparation of biaryl compounds

Details Preparation of biaryl compounds Preparation of biaryl compounds

1983-04-25

1984-11-13

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

546330, 546342, 549 74, 549 79, 560100, 560102, 562492, C07C12166, C07C 69616

Patent

active

044825021

ABSTRACT:
Biaryl compounds are prepared by coupling an arylamine with an aromatic compound in the presence of an alkyl nitrite and about 0.04-0.6 mol of an acid having a dissociation constant of at least about 1.7.times.10.sup.-5 at 25.degree. C. and about 0.08-1.3 mols of a cuprous halide catalyst per mol of the arylamine. The invention has particular utility in the coupling with aromatic compounds of arylamines having acid-sensitive ar-substituents, e.g. flurbiprofen intermediates, such as 2-(4-amino-3-fluorobenzene)propionitrile and alkyl 2-(4-amino-3-fluorobenzene)propionates.

REFERENCES:
patent: 3992459 (1976-11-01), Utne et al.
patent: 4370278 (1983-01-01), Stahly et al.

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