Synthetic ganglioside derivatives

Details Synthetic ganglioside derivatives Synthetic ganglioside derivatives

1994-09-14

1996-10-22

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 41, 536 172, A61K 3170, C08B 3700, C07H 306

Patent

active

055676847

ABSTRACT:
Synthetic compounds which are useful for suppressing an immune response are disclosed. The synthetic compounds have the formula ##STR1## wherein A is a carbohydrate moiety which corresponds to the carbohydrate moiety of a naturally occurring ganglioside, n is 5 to 20 and m is to 20. Also presented are methods for suppressing an immune response in an animal and compositions of matter employing the compounds as shown above.

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Whisler, Ronald L. and Yates, Allan J., Regulation of Lymphocyte Responses by Human Gangliosides, The Journal of Immunology, vol. 125, No. 5 Nov. 1980, pp. 2106-2111.
Yates, A. J., et al, Immunological Properties of Gangliosides, ACS Symp. Series 128 (Cell Surf. Gylcolipids) (1980) pp. 419-433.
M. Hachida, R. Irie, and D. L. Morton, Significant Immunosuppressive Effect of Ganglioside GM.sub.3 in Organ Transplantation, Transplantation Proceedings, Nov. 1-4, 1989 Part I, pp. 1663-1665.
Ladisch et al. Biochem. Biophys. Res. Commun. Sep. 15, 1994, 203(2), 1102-1109.

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