Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-01-16
1989-07-25
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514332, 514334, 514336, 546255, 546257, 546284, 546339, 546342, A61K 3142, C07D21355, C07D40106, C07D40104
Patent
active
048514136
ABSTRACT:
Quinone derivatives represented by the general formula ##STR1## (wherein, R.sup.1 and R.sup.2, the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R.sup.1 and R.sup.2 bind together to form --CH.dbd.CH--CH.dbd.CH--; R.sup.3 is a hydrogen atom or methyl group; R.sup.4 is a nitrogen-containing heterocyclic group which may be substituted; R.sup.5 is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be esterified or amidated; Z is ##STR2## (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in [ ]), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of polyunsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A.sub.2 synthetase, thromboxane A.sub.2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.
REFERENCES:
patent: 3929880 (1975-12-01), Kirchlechner et al.
patent: 4201588 (1980-05-01), Adin et al.
patent: 4271083 (1981-06-01), Morimoto et al.
patent: 4393075 (1983-07-01), Terao et al.
patent: 4489096 (1984-12-01), Terao et al.
Hori et al., Chem. Abstracts, vol. 93, No. 25 (1980), p. 810, Abstract No. 238974r.
Cameron et al., Aust. J. Chem. (1976), vol. 29, pp. 1163-1165.
Kort et al., J. Chem. Soc. (C), 1966, pp. 2190-2196.
Furukawa et al., Chem. Abstr., vol. 84, No. 11 (1976), Abstract No. 74280x.
Babichev et al., Chem. Abstr., vol. 70, No. 25, p. 339, Abstract No. 115062j.
Takada et al., Chem. Abstr., vol. 75, No. 9 (1971), p. 432, Abstract No. 63546b.
Cameron et al., Jour. Chem. Soc. (C), 1969, pp. 1245-1251.
Nishikawa Kohei
Terao Shinji
Rotman Alan L.
Takeda Chemical Industries Ltd.
LandOfFree
Certain benzoquinones, naphthoquinones, corresponding hydroquino does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Certain benzoquinones, naphthoquinones, corresponding hydroquino, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain benzoquinones, naphthoquinones, corresponding hydroquino will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2358355