Use of nikkomycin compounds to treat infections of dimorphic, hi

Details Use of nikkomycin compounds to treat infections of dimorphic, hi Use of nikkomycin compounds to treat infections of dimorphic, hi

1987-07-20

1989-07-25

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 536 23, 536 24, A61K 3171, A61K 3170

Patent

active

048513890

ABSTRACT:
Method of treating an infection of dimorphic, highly chitinous fungi, the method comprising administering therapeutically effective amounts of a nikkomycin or derivative thereof. Treatment is especially suited for infections of medically significant fungi having cell walls with about 10-20% by weight chitin in the parasitic phase. Such fungi include Coccidiodes immitis, Histoplasma capsulatum, Blastomyces dermatitidis, and Paracoccidiodes brasiliensis.

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Becker et al; Antimicrobial Agents and Chemotherapy, 23(6):926-929 (1983).

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