Methods and compositions for the detection and treatment of dise

Details Methods and compositions for the detection and treatment of dise Methods and compositions for the detection and treatment of dise

1993-12-20

1996-10-22

Knode, Marian C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 733, 435822, 435883, 435975, 436513, 436518, G01N 3353, G01N 33554, G01N 33569

Patent

active

055675948

ABSTRACT:
A library of isolated and purified antigens specific for a microorganism is a set of individual molecules. The library forms antigen-antibody complexes useful in the context of diagnosing and treating conditions associated with a specific microorganism such as H. pylori-induced gastro-duodenal disease. For the antigen-antibody complexes in question the antibody is an immunoglobulin, which is IgE if the antigens are allergens. Complexes with IgA, IgG and IgM are also useful. By this multivariate approach, a specific condition is diagnosed with high sensitivity and specificity by determining whether complexes form between a specific antigen library and a biological sample which contains immunoglobulins from an individual. Such libraries also are useful for immunotherapy.

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