Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-

Details Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan- Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-

1974-12-10

1978-05-09

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

542416, 54429386, 2603265M, 544 58, 424246, 424248, 544131, 424250, 424267, 544114, 424270, 424273R, 544120, 424274, 424275, 544122, 424285, 544139, 544140, 544141, 544133, 544146, 544152, 544224, 544238, 544335, 544336, 544406, 260307FA, 26029386, 26032635, 26032625, 2603068R, 26032636, 2603322R, 2603323R, 2603473, 2603475, 548378, 548374, 548336, 2603265J, 42424851, 548343, 424273P, 548342, 42424854, A61K 31505, C07D23926

Patent

active

040887642

ABSTRACT:
The present invention relates to new pharmacologically valuable derivatives of 1-phenoxy-3-amino-propan-2-ol having the formula ##STR1## Wherein A denotes -CH.sub.2 -alkoxy, -O-alkoxyalkyl, -O-hydroxyalkyl, or ##STR2## R.sub.1 denotes hydrogen or methyl, Het denotes the radical of a pyrrole, pyrazole, imidazole, furane, thiophene, thiazole, pyridine, pyridazine, pyrimidine or pyrazine, which can additionally be substituted by one or more methyl groups, said radical is linked through a C atom, and R.sub.2 and R.sub.3 denote hydrogen, alkyl, alkenyl or cycloalkyl or conjointly with the N atom to which they are linked, and optionally with a further oxygen or sulfur hetero-atom, denote a saturated, 5-membered or 6-membered, monocyclic, heterocyclic structure, and alkyl radicals contain 1 to 4 carbon atoms, alkoxy radicals contain 1 to 4 carbon atoms, alkenyl radicals contain 3 or 4 carbon atoms and cycloalkyl radicals contain 5 to 7 carbon atoms; and aldehyde condensation products and acid addition salts thereof.

REFERENCES:
patent: 3646057 (1972-02-01), Beaman et al.
patent: 3686206 (1972-08-01), Posselt et al.
patent: 3830806 (1974-08-01), Raabe et al.
patent: 3852291 (1974-12-01), Augstein et al.
patent: 3940406 (1976-02-01), Raabe et al.
patent: 3969363 (1976-07-01), Raabe et al.

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