Quaternary ammonium salts of aromatic amine compounds, their pre

Details Quaternary ammonium salts of aromatic amine compounds, their pre Quaternary ammonium salts of aromatic amine compounds, their pre

1994-11-21

1997-10-07

Chang, Ceila

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514318, 514321, 514322, 514323, 514326, 514327, 514331, 546193, 546194, 546198, 546199, 546201, 546203, 546205, 546213, 546217, 546224, 546233, A61K 31445, C07D40912, C07D21114

Patent

active

056748817

ABSTRACT:
The present invention relates to quaternary ammonium salts of the formula ##STR1## in which: J is either a group Ar--CXX'--CX" or a group Ar--(CH.sub.2).sub.x CH.sub.1, in which:

REFERENCES:
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patent: 5089251 (1992-02-01), Mosse et al.
Burger "Medicinal Chemistry" Interscience Publisher, p. 42 (1960).
Pine "Organic chemistry" pp. 98-102 1987.
Mountcastle "Medical physiology" 300-303 1968.
"Synthesis and Local Anesthetic Activity of N-Diethylaminoacetyl Derivatives of Naphthylalkylamines", Journal of Medicinal Chemistry, vol. 14, No. 9, 1971, Washington US, pp. 896-897.
"Central Nervous System Activity of Ethyl 1-Naphthylalkylcarbamates", Journal of Medicinal Chemistry, vol. 13, No. 4, 1970, Washington US, pp. 747-748.
"Effects on the Isolated Human Bronchus of SR 48968, a Potent and Selective Nonpeptide Antagonist of the Neurokinin A (NK.sub.2) Receptors", Chemical Abstracts, vol. 118, Columbus, Ohio, US:Abstract No. 32786 (1993).

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