Acylaminoalkanoyl urethanes or thiourethanes

Details Acylaminoalkanoyl urethanes or thiourethanes Acylaminoalkanoyl urethanes or thiourethanes

1985-03-22

1987-01-13

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

562439, 548953, 514333, 514339, 514341, 514343, 514397, 514414, 546147, 546256, 546268, 546273, 546276, 546278, 546281, 548188, 548336, 548356, 548454, 548455, 548456, 548465, 548467, 548468, 548517, 548527, 548533, 560 16, 560 19, 560 24, 560 34, 562426, 562433, C07D20704, A61K 3140, A61K 3134, A61K 3138

Patent

active

046365222

ABSTRACT:
Compounds of the formula ##STR1## wherein Z is oxygen or sulfur are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

REFERENCES:
patent: 4311705 (1982-01-01), Ondetti et al.
patent: 4329473 (1982-05-01), Almquist et al.
patent: 4470973 (1984-09-01), Natarajan et al.
patent: 4524212 (1985-06-01), Gordon et al.
Meyer et al., "Novel Synthesis of . . . ", J. Med. Chem., 1981, vol. 24, pp. 964-969.
Almquist et al., "Derivatives of Potent Angiotensin Converting Enzyme Inhibitor . . . ", J. Med. Chem, 1982, vol. 25, 1292-1299.

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