Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1989-06-29
1990-05-08
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435813, 435818, 435911, C12P 718, C12R 1645
Patent
active
049238124
ABSTRACT:
A process is disclosed for continuously producing erythritol by cultivating erythritol-producing microorganisms under aerobic conditions. The process comprises the steps of: maintaining the concentration of dissolved oxygen in a culture broth in a fermentation tank at not less than 0.2 ppm; separating a part of the culture broth into a concentrated liquid in which the concentration of cells is increased and a clarified liquid by a cell separator; returning the concentrated liquid to the fermentation tank; controlling an amount of the clarified liquid to be extracted outside an erythritol-producing system and an amount of the culture broth and/or the concentrated liquid to be extracted outside the producing system such that the concentration of the cells in the culture broth in the fermentation tank may be kept in a range from 40 to 200 g/l when calculated as a weight of dried cells; and recovering erythritol from the clarified liquid.
The clarified liquid containing erythritol may be separated from the culture broth by a cell separator arranged inside the fermentation tank, and the extracting amount of the erythritol-containing clarified liquid separated by the cell separator and an amount of the culture broth to be extracted may be controlled such that the concentration of the cells in the culture broth may be kept at 40 to 200 g/l when calculated as a weight of dried cells.
REFERENCES:
patent: 2986495 (1961-05-01), Onishi
patent: 3756917 (1973-09-01), Dezeeuw et al.
"Erythritol Production by a Yeastlike Fungus", G. J. Hanjny et al., Applied Microbiology, vol. 12, No. 3, May 1964, pp. 240-246.
"Continuous Culture with Complete Cell . . . ", Olee Holst et al., Applied Microbiology and Biotechnology, vol. 23, 1985, pp. 10-14.
"Huge Plant for Ethanol and HFCS", Charles E. Morris, Food Engineering, Jun. 1983, pp. 107-112.
"Ethanol Production by Cell Recycling with Hollow Fibers", Yoshinori Nishizawa et al., J. Ferment. Tech., vol. 61, No. 6, 1983, pp. 599-605.
"High Concentration Cultivation . . . ", Masayuki Taniguchi et al., Applied Microbiology and Biotechnology, vol. 25, 1987, pp. 438-441.
"A Filter Fermenter-Apparatus and Control Equipment", Milan Dostalek et al., Biotech. and Bioengineering, vol. XXIV, 1982, pp. 2077-2086.
Hattori Nobuo
Horikita Hiroyuki
Kawaguchi Gaku
Maeda Toshihiro
Takagi Yahei
Lilling Herbert J.
NGK Insulators Ltd.
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