Probenecidoxymethyl and 1-ethyl esters of ampicillin

Details Probenecidoxymethyl and 1-ethyl esters of ampicillin Probenecidoxymethyl and 1-ethyl esters of ampicillin

1974-07-30

1976-01-06

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, C07D49968

Patent

active

039311503

ABSTRACT:
New ampicillin derivatives, probenecidoxymethyl and 1-ethyl esters of ampicillin and their pharmaceutically acceptable salts, useful as antibiotics. A method for preparing these antibiotics by condensing probenecidoxymethyl or 1-ethyl halide with an acid salt of 6[D(-)-.alpha.-azidophenylacetamido] penicillanic acid, hydrogenating the azido group and isolating the product as a pharmaceutically acceptable salt of an acid. Pharmaceutical preparations containing the new antibiotics.

REFERENCES:
patent: 3697507 (1972-10-01), Fredericksen et al.
Remington's Pharmaceutical Sciences, 13th Ed., p. 1022 (1965).

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