Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1991-11-22
1993-11-16
Hill, Jr., Robert J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 697, 4352523, 4353701, C07K 1300, C12N 1562
Patent
active
052625222
ABSTRACT:
A receptor protein comprising a gp130 polypeptide linked to a single-chain leukemia inhibitory factor receptor (LIF-R) polypeptide is capable of binding both oncostatin M and leukemia inhibitory factor (LIF). The receptor protein binds LIF with greater affinity than does the single-chain LIF-R polypeptide alone. The receptor may be produced as a fusion protein in recombinant cells. The gp130 polypeptide binds oncostatin M, but with lower affinity than does the inventive receptor protein.
REFERENCES:
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5155027 (1992-10-01), Sledziewski et al.
Hibi et al., "Molecular Cloning and Expression of an IL-6 Signal Transducer, gp130", Cell 63:1149 (Dec. 1990).
Gearing et al., "Leukemia inhibitory of factor receptor is structurally related to the IL-6 signal transducrer, gp130", The EMBO Journal 10(10):2839 (Oct. 1991).
Gearing and Cosman, "Homology of the p40 Subunit of Natural Killer Cell Stimulatory Factor (NKSF) with the Extracellular Domain of the Interleukin-6 Receptor", Cell 66:9 (Jul. 1991).
Linsley et al., "Identification and Characterization of Cellular Receptors for the Growth Regulator, Oncostatin M", J. Biol. Chem. 264(8):4282 (Mar. 1989).
Lesslauer et al., "Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide-induced lethality", Eur. J. Immunol 21:2883 (Nov. 1991).
Peppel and Beutler, "Chimeric TNF-R--IgG Molecule Acts As Soluble Inhibitor of TNF Mediated Cytotoxicity", J. Cell. Biochem. (ABSTR), Suppl. 15F (Apr. 1991).
Brown et al., "Regulation of IL-6 Expression by Oncostatin M", J. Immunol. 147:2175 (Oct. 1991).
DeWit et al., "Interleukin-6 concentrations in the serum of patients with AIDS-associated Kaposi's sarcoma during treatment with interferon-alpha", J. Intern. Med. 229:539 (Jun. 1991).
Hill Jr. Robert J.
Immunex Corporation
Seese Kathryn A.
Ulm John D.
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