Method to prepare a neurotrophic composition

Details Method to prepare a neurotrophic composition Method to prepare a neurotrophic composition

1988-04-22

1990-05-08

Stone, Jacqueline M.

Drug, bio-affecting and body treating compositions

Extract, body fluid, or cellular material of undetermined...

Derived from musculoskeletal system, other than cardiac muscle

514 21, 514885, 530350, 530841, 530326, A61K 3702

Patent

active

049236962

ABSTRACT:
The present invention is based on the discovery that amyotrophic lateral sclerosis (ALS), Parkinson disease and Alzheimer disease are due to lack of disorder-specific neurotrophic factors. Specific neurotrophic factors of .about.20-22 kD and .about.16-18 kD have been isolated from rat and human skeletal motor neurons, respectively, and purified. With tissue culture, the presence or absence of the specific neurotrophic factors provided herein can be assessed in ALS. If there is a deficiency, extracted and purified neurotrophic factors specific to the motor neuronal network or system can be administered to ALS-affected individuals.

REFERENCES:
Esch et al., PNAS U.S.A., vol. 82, (1985), pp. 6507-6511.
Gimenez-Gallego et al., Science, vol. 230, (1985), pp. 1385-1388.
Appel, Ann. Neurol., 10:499-505, (1981).
Smith and Appel, Science, 219:1079-1081, (1983).
Smith et al., J. Cell Biol., 101:1608-1621.
Vaca et al., Dev. Brain Res., 19:37-46, (1985).
Smith et al., J. Neurosci., 6(2):439-447, (1986).
McManaman et al., J. Biol. Chem., 263:5890-5897, (1988).

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