4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of

Details 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of 4-Alkylsubstituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of

1980-04-04

1984-01-31

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

548544, A61K 3140, C07D207456

Patent

active

044289596

ABSTRACT:
Novel 4-alkylsubstituted-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.

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patent: 3340263 (1967-09-01), Staehelin et al.
patent: 3948941 (1976-04-01), Patton
patent: 4194982 (1980-03-01), Chou
Liao, et al., "Arch. Biochem. Biophys.", vol. 154, 1973, pp. 68-75.
Harlay, "J. Pharm. Chim.", vol. 24, 1936, pp. 537-548.
Skinner, et al., "J. Am. Chem. Soc.", vol. 73, 1951, pp. 2230.
Skinner, "J. Am. Chem. Soc.", vol. 70, 1948, pp. 4011.

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