Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1980-12-29
1984-01-31
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548206, 548213, C07D27502, A61K 3144
Patent
active
044289561
ABSTRACT:
4-Hydroxy-5-substituted-3(2H)-isothiazolone-1,1-dioxide derivatives of the formula: ##STR1## where X and Y are independently selected from the group consisting of hydrogen, halogen, and C.sub.1-6 alkyl; provided that positions 2 and 6 of the substituted phenyl moiety may not be substituted; and n is 0 or 1;
REFERENCES:
patent: 3849430 (1974-11-01), Lewis
patent: 4067878 (1978-01-01), Miller
patent: 4346094 (1982-08-01), Beck et al.
Lewis et al., J. Het. Chem., 8, p. 591 (1971).
Burger, Medicinal Chemistry, p. 42.
Randall et al., J. Med. Chem., 22, p. 608.
Cragoe, Jr. Edward J.
Rooney Clarence S.
Williams Haydn W. R.
Cheng Theresa Y.
Daus Donald G.
Hendricks G.
Merck & Co. , Inc.
Merck Sharp & Dohme (I.A.) Corp.
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