Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1992-02-27
1993-07-27
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 267, 536 2714, 514 43, 514 45, 514 47, 514 48, 514 49, 514 50, 514 51, C07H 19067, C07H 1910, C07H 19173, C07H 1920
Patent
active
052311740
ABSTRACT:
The present invention is concerned wtih new 2'-isomeric 2 2',3'-dideoxy-2'.beta.-D-nucleosides and their derivatives where the base moiety has .beta.-stereochemistry but is transposed from the normal 1'-position to the 2'-position and the carbohydrate moiety has the D-configuration at the 4'-position. These compounds are resistant towards hydrolytic cleavage of the glycosidic bond and are resistant to enzymatic deamination. They have potential in the treatment or prophylaxis of viral infections, particularly retroviral infections and especially AIDS.
REFERENCES:
patent: 4115555 (1978-09-01), Wade et al.
patent: 4713372 (1987-12-01), Schaumberg et al.
patent: 4724232 (1988-02-01), Rideout et al.
patent: 4861759 (1989-08-01), Mitsuya et al.
patent: 4873228 (1989-10-01), Schmalzl et al.
patent: 4879277 (1989-11-01), Mitsuya et al.
patent: 4880782 (1989-11-01), Eckstein et al.
patent: 4918056 (1990-04-01), Bobek et al.
patent: 4990498 (1991-02-01), Suhadolnik
patent: 4997818 (1991-03-01), McCaffrey et al.
patent: 5026687 (1991-06-01), Yarchoan et al.
patent: 5028595 (1991-07-01), Soo
patent: 5039667 (1991-08-01), Tyrrell et al.
Crane et al., "Isonucleosides from Glucosamine," J. Carbohydrates Nucleosides Nucleotides, 7(5), 281-296 (1980).
Doboszewski et al., "Synthesis of C-Nucleoside Analogues of 2',3'-Dideoxycytidine, 3'-Azido-2',3'-dideoxyuridine (CS-87), and 2',3'-dideoxy-2',3'-didehydrocytidine," J. Org. Chem., 53, 2777-2782 (1988).
Chu et al., "Structure-Activity Relationships of Pyrimidine Nucleosides as Antiviral Agents for Human Immunodeficiency Virus Type I in Peripheral Blood Mononuclear Cells," J. Med. Chem., 32, 612-617 (1989).
Frank et al., "Anabolism and Mechanisms of Action of Ro24-5098, an Isomer of 2',3'-Dideoxyadenosine (ddA) with Anti-HIV Activity", Annals New York Academy of Sciences 1990, 616, 408.
Brown Johnnie R.
Crane L. Eric
University of Iowa Research Foundation
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