Method of improving oral bioavailability of carbamazepine

Details Method of improving oral bioavailability of carbamazepine Method of improving oral bioavailability of carbamazepine

1992-07-01

1993-07-27

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514277, 514279, 514964, 536103, 424464, 424468, A61K 3170, C08B 3716

Patent

active

052310892

ABSTRACT:
The invention provides a method for improving the oral bioavailability of carbamazepine by administering per os, to a warm-blooded animal in need of carbamazepine therapy, a therapeutically effective amount of carbamazepine complexed with cyclodextrin selected from the group consisting of hydroxypropyl and hydroxyethyl derivatives of .beta.- and .gamma.-cyclodextrin.

REFERENCES:
patent: 4727064 (1988-02-01), Pitha
patent: 4764604 (1988-08-01), Muller
patent: 4983586 (1991-01-01), Bodor
patent: 5024998 (1991-06-01), Bodor
patent: 5051406 (1991-09-01), Satoh
Pharmaceutical Research, vol. 8, No. 10, Oct. 1991 (Supplement), Abstract PDD7038 (Choudhury et al.).
Brewster et al., J. Pharm. Sci., vol. 80, No. 4, Apr. 1991.
Pharmaceutical Research, vol. 8, No. 10, Oct. 1991 (Supplement), abstract PDD7038 (Choudhury et al.).
Morselli, Chapter 33 in Antiepileptic Drugs, Third Edition, ed. R. Levy et al., Raven Press, Ltd., New York, 1989, pp. 473-490.
The Pharmacological Basis of Therapeutics, ed. Louis S. Goodman and Alfred Gilman, fifth edition, MacMillan Publishing Co., Inc. New York, 1975, p. 211.
Monaco et al., J. Int. Med. Res. 12 (1984), pp. 108-113.
Eadie et al., The Medical Journal of Australia, vol. 146, Mar. 16, 1987, pp. 313-316.
Bloomer et al., Clinical Pharmacy, vol. 6, Aug. 1987, pp. 646-649.
Maas et al., Therapeutic Drug Monitoring 9, (1987), pp. 28-33.
Graves et al., Epilepsia, 24 (1983), pp. 604-608.
Neuvonen et al., Br. J. Clin. Pharmac. 24 (1987), pp. 839-841.
Gerardin et al., Epilepsia 31 (3), (1990), pp. 334-338.

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