Treatment of skin diseases and tumors with esters and amides of

Details Treatment of skin diseases and tumors with esters and amides of Treatment of skin diseases and tumors with esters and amides of

1992-01-22

1993-07-27

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514546, 514547, 514552, 514625, 514627, 514629, 514859, 514863, A61K 31715

Patent

active

052310876

ABSTRACT:
Noninfectious inflammatory and hyperpigmentation skin diseases, thermal injuries and premalignant skin tumors induced by radiation or virus, in both humans and animals, are treated with topical formulations of an ester or amide of a monocarboxylic acid, the acid moiety of which is 9 to 18 carbon atoms.

REFERENCES:
patent: 3535422 (1970-10-01), Cox et al.
patent: 4557935 (1985-12-01), Ekenstam et al.
patent: 5057500 (1991-10-01), Thornfeldt
patent: 5057501 (1991-10-01), Thornfeldt
Calabresis, P., et al., Goodman and Gilman, The Pharmacological Basis of Therapeutics, Eighth Edition, pp. 1205-1207, Pregamon Press, New York (1990).
Kato, A., et al., "Antitumor Activity of Monoglycerides and Other Esters of Fatty Acids", J. of Antibiotics, vol. XXII, No. 2, pp. 83-84 (Feb. 1969).
Kabara, J., et al., "Examinations on Antitumor, Immunological, and Plant-Growth Inhibitory Effects of Monoglycerides of Caprylic, Capric, and Lauric Acids and Related Compounds", The Pharmacological Effect of Lipids II, The American Oil Chemists' Society, Champaign, Ill. (ed. Kabara), Chapter 23, pp. 263-267 (1985).
Stryer, L., Biochemistry, Third Ed. p. 988, Freeman and Co., New York (1988).

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