Method for the treatment of atherosclerosis, thrombosis, and per

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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A61K 3700

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052310809

ABSTRACT:
The invention relates to a method for the treatment of atherosclerosis, thrombosis and/or of peripheral vessel disease by administration of angiotensin converting enzyme inhibitors. Administration of compounds of the formula I ##STR1## in which n is 1 or 2, R, R.sup.1, R.sup.2 and R.sup.3 are identical or different and each denotes hydrogen or an organic radical, and R.sup.4 and R.sup.5 form, together with the atoms carrying them, a mono-, bi- or tricyclic heterocyclic ring system, is preferred. The invention also relates to angiotensin converting enzyme inhibitors and to agents containing them for administration for the treatment of the abovementioned diseases.

REFERENCES:
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4374847 (1983-02-01), Gruenfeld
patent: 4425355 (1984-01-01), Hoefle et al.
patent: 4442089 (1984-04-01), Horovitz
patent: 4515803 (1985-05-01), Henning et al.
patent: 4525301 (1985-06-01), Henning et al.
patent: 4558037 (1985-12-01), Chan et al.
patent: 4558064 (1985-12-01), Teetz et al.
patent: 4558065 (1985-12-01), Urbach et al.
patent: 4584285 (1986-04-01), Doll et al.
patent: 4591598 (1986-05-01), Urbach et al.
patent: 4614805 (1986-09-01), Urbach et al.
patent: 4620012 (1986-10-01), Henning et al.
patent: 4624962 (1986-11-01), Henning et al.
patent: 4659838 (1987-04-01), Lerch
patent: 4663307 (1987-05-01), Girard et al.
patent: 4668796 (1987-05-01), Geiger et al.
patent: 4668797 (1987-05-01), Urbach et al.
patent: 4678800 (1987-07-01), Stanton et al.
patent: 4684662 (1987-08-01), Henning et al.
patent: 4691022 (1987-09-01), Henning et al.
patent: 4714708 (1987-12-01), Urbach et al.
patent: 4727160 (1988-02-01), Teetz et al.
patent: 4808573 (1989-02-01), Gold et al.
patent: 4822894 (1989-04-01), Geiger et al.
patent: 4831157 (1989-05-01), Gold et al.
patent: 4849524 (1989-07-01), Henning et al.
patent: 4868307 (1989-09-01), Barton et al.
patent: 4886827 (1989-12-01), Urbach et al.
patent: 4920144 (1990-04-01), Urbach et al.
patent: 4983623 (1991-01-01), Henning et al.
patent: 4997260 (1991-12-01), Henning et al.
Leonard et al., J. Am. Chem. Soc., 78, 3463 (1956).
Leonard et al., J. Am. Chem. Soc., 81, 5627 (1959).
Koelsch et al., J. Org. Chem., 26, 1104 (1961).
Griot et al., Helv. Chim. Acta, 42, 121 (1959).
Bonnett et al., J. Chem. Soc., 2087 (1959).
Battersby et al., J. Chem. Soc., 4333 (1958).
Rosenblatt et al., The Chemistry Of Functional Groups. Supplement F: The Chemistry of Amino, Nitroso and Nitro Compounds And Their Derivatives. Part II, S. Patai, ed., Wiley & Sons: New York 1982, pp. 1100-1104.
L. W. Haynes, Enamines, A. G. Cook, ed., Marcel Decker, Inc.: 1969, pp. 68-79, 261-269, 413.
Fieser & Fieser, Reagents For Organic Synthesis, vol. 1, pp. 644-651 (1967).
Boehme et al., Iminium Salts in Organic Chemistry, Part I (E. C. Taylor, ed.), Wiley & Sons: New York, 1976, p. 143.
S. Dayagi et al., The Chemistry Of Functional Groups. The Chemistry Of The Carbon-Nitrogen Double Bond, S. Patai, ed., Wiley & Sons: New York, 1970, p. 119.
W. Greenlee et al., J. Med. Chem., 28, 434-442 (1985).
K. Ogawa et al., J. Chem. Soc., Perkin Trans. I, 3031-3035 (1982).
R. Bacon and D. Stewart, J. Chem. Soc. (C), 1384-1387 (1966).
R. Bacon et al., J. Chem. Soc. (C), 1388-1389 (1966).
Patchett et al., Nature, 288, 280-283 (1980).
Booth et al., Chemistry and Industry, 466-467 (1956).
Booth et al., J. Chem. Soc., Part I, 1050-1054 (1959).
Murakoshi et al., Chemical Abstracts, 61, 9465(e) (1964).
Cushman et al., Fed. Proc., 38 (13), 2778-2782 (1979).
Houben-Weyl, Methoden der Organischen Chemie, 7(2b), 1403-1404 (1976).
Katritskaya, Dzh. Lagorskaya Khimia Geterosikl. Soedin., Moskow 1963, pp. 155-158.
Anderson, Jr. et al., J. Org. Chem., 43(1), 54-57 (1978).
Bertho et al., Synthesen In Der 2-Azabicyclo[0.3.3]-octan-Reihe, Chemische Berichte, 92(7), 2218-2235 (1959).
Farkas et al., J. Org. Chem., 22, 1261-1263 (1957).
Taylor et al., J. Org. Chem., 38(16), 2817-2821 (1973).
Taylor et al., Heterocycles, 25, 343-345 (1987).
English language translation of Mitzlaff et al., Liebig's Ann. Chem., 1713-1733 (1978).
Quarterly Reviews 25: 323-341 (1971).
Chem. Berichte 86: 1524-1528 (1953).
Chem. Abst. 49/1955/3009c.
Xiang et al. Chem Abstracts, CA (100):150853c (1984), p. 3.
B. A. Schoelkens et al., "Programm/Abstracts", p. 20.
M. Catalano et al., Angiology--Journal of Vascular Diseases, vol. 36, No. 5, May 1985, 293-296.
Noriyuki Someya et al., Journal of Cardiovascular Pharmacology, vol. 6, No. 5, 1984, 840-843.
G. Trubestein et al., DTSCH. MED. WOCHENSCHR., vol. 109, No. 22, 1984, 857-860.
Sakae Wasa et al., Atherosclerosis, vol. 40, 1981, 263-271.
Seiji Miyazaka et al., British Med. Journal, vol. 284, No. 6312, Jan., 1982, 310-311.
Kiyoshi Yamagami et al., Folia Opthalmol. Jpn., vol. 34, No. 2, 1983, 290-297.

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