2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and

Details 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and

1984-06-21

1986-02-04

Jiles, Henry H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514236, 514269, 544123, 544300, C07D40112, C07D40114, C07D41314, A61K 31505

Patent

active

045686777

ABSTRACT:
1,4-Dihydropyridine derivatives of the formula: ##STR1## wherein R is aryl or heteroaryl; R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl or 2-methoxyethyl; X is a 5 or 6 membered nitrogen-containing heterocyclic ring which is substituted with one or more hydroxyl or oxo groups and which may optionally be fused to a further 5 or 6 membered nitrogen-containing heterocyclic ring, and which may optionally be further substituted in the heterocyclic ring or further fused heterocyclic ring; Y is --(CH.sub.2).sub.n --, --CH.sub.2 CH(CH.sub.3)-- or --CH.sub.2 C(CH.sub.3).sub.2 --; and n is 1 to 3 when X is linked to Y by a ring carbon atom, or 2 or 3 when X is linked to Y by a ring nitrogen atom; and their pharmaceutically acceptable salts, and pharmacuetical preparation containing such compounds, have utility as anti-ischaemic and antihypertensive agents.

REFERENCES:
patent: 4430333 (1984-02-01), Campbell et al.
Chemical Abstracts, 101: 110954a.
Schramm, M. et al, "Novel Dihydropyridines with Positive Inotropic Action", Nature, vol. 303, Jun. 9, 1983, pp. 535-537.
Bossert, F. et al, "4-Aryldihydropyridines", Angew. Chem. Int., Ed. Engl., 20, (1981) pp. 762-769.

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