N-Acyl-.gamma.-glutamyl imino and amino acids and esters

Details N-Acyl-.gamma.-glutamyl imino and amino acids and esters N-Acyl-.gamma.-glutamyl imino and amino acids and esters

1984-06-29

1986-02-04

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

548533, 548470, 548492, 548410, 548491, 546147, C07C10352, C07D21700, C07D49100, C07D20942, C07D20944, C07D20700

Patent

active

045684898

ABSTRACT:
Compounds of the formula ##STR1## wherein X is various imino or amino acids or esters are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and depending upon the definition of X also possess enkephalinase inhibition activity.

REFERENCES:
patent: 2581814 (1952-01-01), Plentl
patent: 2933487 (1960-04-01), Amiard et al.
patent: 2970136 (1961-01-01), Amiard et al.
patent: 3331828 (1967-07-01), Inamine et al.
patent: 4052372 (1977-10-01), Finot et al.
patent: 4052511 (1977-10-01), Cushman et al.
patent: 4105789 (1978-08-01), Ondetti et al.
Ondetti et al., "The Use of an Active Site Model . . . ", Peptides, Proc. Fifth Amer. Peptide Symposium, 1977, pp. 576-578.

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