Glycyl tRNA synthetase from streptococcus pneumoniae

Details Glycyl tRNA synthetase from streptococcus pneumoniae Glycyl tRNA synthetase from streptococcus pneumoniae

1998-01-23

2000-04-18

Hobbs, Lisa J.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

435 6, 435440, 5303871, 536 232, C12N 900, C12N 1500, C12Q 168, C07H 2104

Patent

active

060514124

ABSTRACT:
The invention provides glyS (beta) and glyS (alpha) polypeptides and DNA (RNA) encoding glyS (beta) and glyS (alpha) polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glyS (beta) and glyS (alpha) polypeptides to screen for antibacterial compounds.

REFERENCES:
Webster et al., "Primary Structures of Both Subunits of Escherichia coli Glycyl-tRNA Synthetase," Journal of Biological Chemistry, 258(17) p. 10637-10641 (1983).
Fleischmann et al., "Whole-Genome Random Sequencing and Assembly of Haemophilius influenzae Rd.," Science, 269 p. 496-512 (1995).
R. Calendar et al., "Purification and Physical Characterization of Tyrosyl Ribonucleic Acid Synthetases from Escerichia coli and Bacillus subtilis", Biochemistry, 5(5) p. 1681-1690.
J. Hughes et al., "How Does Pseudomonas Fluorescens, the Producing Organism of the Antibiotic Pseudomonic Acid A, Avoid Suicide?", FEBS Letters, 122(2) p. 322-324 (1980).
Niyomporn et al., "Biosynthesis of the Peptidogylcan of Bacterial Cell Walls", J. Biol. Chem., 243(4) p. 773-778 (1968).
Lindler, et al., "Molecular Cloning and Characterization of a Streptococcus DNase Necessary for Repair of DNA Damage Induced by UV Light and Methyl Methanesulfonate", Journal of Bacteriology, vol. 169, No. 7: pp. 3199-3208, 1987.

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