Effervescent pharmaceutical composition containing ibuprofen and

Details Effervescent pharmaceutical composition containing ibuprofen and Effervescent pharmaceutical composition containing ibuprofen and

1993-02-08

1996-01-02

Venkat, Jyothsna

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424489, 424501, 514960, A61K 946, A61K 914

Patent

active

054806526

ABSTRACT:
The present invention relates to a novel pharmaceutical composition for the preparation of effervescent powders or tablets incorporating ibuprofen or one of its pharmaceutically acceptable salts as the active ingredient.
This composition comprises:
an effective amount of ibuprofen or one of its pharmaceutically acceptable salts;
a pharmaceutically acceptable effervescent system comprising at least one alkaline carbonate and at least one organic acid, preferably in a sufficient amount to give a pH below about 8; and
at least one pharmaceutically acceptable antioxidant in a sufficient amount to stabilize the ibuprofen.
This composition has a remarkable stability both in powder form and in tablet form.

REFERENCES:
patent: 5032384 (1991-07-01), Yeh et al.
patent: 5178878 (1993-01-01), Vuelling et al.
patent: 5180590 (1993-01-01), Carcano et al.

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