Process for preparing biological compositions for use as referen

Details Process for preparing biological compositions for use as referen Process for preparing biological compositions for use as referen

1977-08-22

1978-10-24

Serwin, R.E.

Chemistry: physical processes

Physical processes

Crystallization

23230R, 252408, G01N 3316

Patent

active

041219058

ABSTRACT:
The present disclosure is directed to the preparation of stable aqueous-containing biological compositions capable of use as liquid reference serums in diagnostic chemical analysis using multichannel automated analyzers and having improved storage stability and capable of storage in the liquid state for extended periods of time measured in weeks when stored at 2.degree. to 8.degree. C.; processes for preparing the reference serums and the process of automated analysis utilizing the improved reference serums. The subject materials are prepared by freezing the aqueous-containing labile biologicals rapidly at temperatures ranging from about -20.degree. to about -30.degree. C., removing from about 98 to 99 weight percent of the water therefrom and storing same (as a dehydrated solid) at 2.degree. to 8.degree. C. until desired use. The dehydrated material is then reconstituted by dissolving it in a medium containing from about 20 to about 50 wt. % of an alkylene polyol containing from 2 to 5 carbon atoms with the remainder being water. The thus reconstituted biological compositions can be stored in the liquid state at 2.degree. to 8.degree. C. for periods of 4 to 5 weeks or at -20.degree. C. for months.

REFERENCES:
patent: 2348887 (1944-05-01), Drake
patent: 2664403 (1953-12-01), Weichselbaum
patent: 2770602 (1956-11-01), Weichselbaum
patent: 3409422 (1968-11-01), Gulotta
patent: 3466249 (1969-09-01), Anderson
patent: 3629142 (1971-12-01), Marbach
patent: 3701644 (1972-10-01), Frank
patent: 3856499 (1974-12-01), Frank
patent: 3869269 (1975-03-01), Knapp
patent: 3871855 (1975-03-01), Frank
patent: 3876375 (1975-04-01), Maurukas
patent: 3891420 (1975-06-01), Frank
patent: 3929441 (1975-12-01), Frank
patent: 3934996 (1976-01-01), Frank
patent: 3992181 (1976-11-01), Frank
patent: 4043783 (1977-08-01), Frank

Affiliated with

Also associated with

Rating

Process for preparing biological compositions for use as referen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing biological compositions for use as referen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing biological compositions for use as referen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2334793