Production of solid drug forms

Details Production of solid drug forms Production of solid drug forms

1997-07-01

2000-04-18

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424464, 424467, A61K 920

Patent

active

060512539

ABSTRACT:
Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.

REFERENCES:
patent: 1419147 (1922-06-01), Kloepping
patent: 4059382 (1977-11-01), Kobayashi et al.
patent: 4801460 (1989-01-01), Goertz et al.
patent: 4880585 (1989-11-01), Klimesch et al.
patent: 4957681 (1990-09-01), Klimesch et al.
patent: 5073379 (1991-12-01), Klimesch et al.

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