Imidazolyl or tetrazolyl substituted benzoic acid derivatives an

Details Imidazolyl or tetrazolyl substituted benzoic acid derivatives an Imidazolyl or tetrazolyl substituted benzoic acid derivatives an

1986-11-10

1988-07-05

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514381, 548253, 548341, A61K 3141, A61K 31415, C07D22314, C07D25704

Patent

active

047555181

ABSTRACT:
Novel benzoic acid or benzoic acid ester derivatives, pharmaceutical compositions and methods of use thereof are the present invention. Utility is for the treatment of arthritis, asthma, Raynaud's disease, inflammatory bowel disorders, trigeminal or herpetic neuralgia, inflammatory eye disorders, psoriasis, dental pain, and headaches, particularly vascular headaches, such as migraine, cluster, mixed vascular syndromes, as well as nonvascular, tension headaches.

REFERENCES:
patent: 3514383 (1970-05-01), Beal et al.
patent: 3953499 (1976-04-01), Pike et al.
Baer, "Tetrahedron Letters", No. 51, pp. 4697-4700 (1976).
Fujisawa et al., "Chemistry Letters, Chem. Soc. Japan", pp. 71-74 (1982).
Leblanc et al., J. Org. Chem, 51, pp. 789-793 (1986).

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